A series of new 4-thiazolidinone derivatives of 2-(4-chlorophenyl)-3-(6-(thiophen-2-yl)-4-p-tolyl-4H-1,3-oxazin-2-yl)-
thiazolidin-4-one (7h-m) are synthesized because of its wide range of biological activities.1H & 13C NMR, IR studies were
applied for the elucidation of all the synthesized compounds. All the synthesized compounds have been tested for antidiabetic
and antioxidant activity in vitro method against standard. The analogs 7h-m was evaluated for α-amylase and α-glucosidase
inhibitory potential. The structures of all the compounds have been screened for antioxidant activity using DPPH radical
scavenging assay, NO scavenging method. Molecular docking studies were accomplished in addition to understand the
binding affinity of those compounds with PDBID 2HR7 which showed that the synthesized derivatives bind in the lively
binding site of the target protein
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