1 The pharmacokinetics and haemodynamic effects of nisoldipine on long term i.v. infusion of 2.40 mg and 9.59 mg in 25 h were studied in six healthy subjects. Liver blood flow at 0.8 and 24 h was assessed by measuring indocyanine green (ICG) clearance.2 After high-dose nisoldipine, systemic clearance was 0.99 ± 0.16 1 min-', volume of distribution was 5.8 ± 1.5 1 kg-' and elimination half-life was 10.7 ± 2.4 h. The pharmacokinetic parameters were similar after low-dose nisoldipine. 3 No significant changes in apparent liver blood flow were observed after either highdose or low-dose nisoldipine. 4 Systolic blood pressure did not change, whereas diastolic blood pressure decreased by approximately 10% during both treatments. Maximal increase in heart rate was approximately 37% at high-dose infusion, whereas this was one half lower during the low-dose regimen. 5 Increased infusion rate results in an unfavourable shift in the haemodynamic effect profile of nisoldipine.