The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most active antimicrobial agent tested against the gram-negative bacilli. It was less active than a few of the other antimicrobial agents against enterococci and Staphylococcus aureus.
The in vitro activity of a new oral antimicrobial agent, Mk-0366 (AM-715), was compared with those of rosoxacin, ampicillin, erythromycin, and tetracycline against Neisseria gonorrhoeae. Mk-0366 was as active as rosoxacin and more active than the other three antimicrobial agents. It inhibited all isolates, regardless of ,B-lactamase activity, at a concentration of 0.03 ,ug/ml.Mk-0366 (AM-715) is an antibacterial organic acid structurally related to nalidixic acid. Unlike nalidixic acid, Mk-0366 exhibits a very broad spectrum of antibacterial activity against both gram-negative and gram-positive bacteria (5). In experimental systemic and urinary bladder-kidney infections in mice, Mk-0366 was found to be five times as active as pipemidic acid and nalidixic acid (4). This study was conducted to evaluate the in vitro activity of Mk-0366 against f,-
The in vitro activities of three new P-lactam antimicrobial agents, cefodizime, ceftazidime, and aztreonam (formerly azthreonam), were compared with those of cefotaxime, cefuroxime, cefoxitin, and penicillin against 100 3-lactamase-negative and 42 13-lactamase-positive Neisseria gonorrhoeae strains. The three new antimicrobial agents showed excellent activity against N. gonorrhoeae regardless of P-lactamase production. Cefodizime
Four hundred and seventy-three men and women at high risk for sexually transmitted disease were tested for the presence of Chlamydia trachomatis in the urethra or the endocervix. Four groups were involved in this multicenter study of two direct fluorescent-antibody microscopy tests, Kallestad Pathfinder and Syva Microtrak, compared with culture techniques. Results from the test sites indicated that there was no significant difference overall in the sensitivity and specificity of the two test kits. However, there was some interlaboratory variation seen in-the sensitivity of the microscopy, but little difference in the specificity. Either kit could bé an effective screening method for C. trachomatis in high-risk populations.
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