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In the intraclass correlation model when the variance 0'2 and the intraclass correlation coefficient p are both unknown, Tukey's confidence intervals for the contrasts in the means are obtained for the fixed sample and the sequential case. In the latter case confidence intervals of fixed width are obtained and the cost of not knowing 0'2 and p has been studied. From these results parallel results for Scheffe's confidence intervals can easily be obtained. A recommendation for the choice between the two is also made.

SummarySchatzoff [9] obtained the forms of the probability density function (pdf) and the cumulative distribution function (cdf) of the product of independent beta random variables when their parameters had some special values. The forms, however, did not indicate the constants explicitly. In this paper his approach is modified so as to allow presentation of explicit expressions for the pdf and cdf of the product of independent beta random variables (without restriction to the values of the parameters) in neat forms. Applications in multivariate analysis are given for the central and the non-central cases.

Inhibition of type 1 interferon (IFN-I) signaling promotes the control of persistent virus infection, but the underlying mechanisms remain poorly understood. Here, we report that genetic ablation of Ifnar1 specifically in natural killer (NK) cells led to elevated numbers of T follicular helper cells, germinal center B cells, and plasma cells and improved antiviral T cell function, resulting in hastened virus clearance that was comparable to IFNAR1 neutralizing antibody treatment. Antigen-specific B cells and antiviral antibodies were essential for the accelerated control of LCMV Cl13 infection following IFNAR1 blockade. IFNAR1 signaling in NK cells promoted NK cell function and general killing of antigen-specific CD4 and CD8 T cells. Therefore, inhibition of IFN-I signaling in NK cells enhances CD4 and CD8 T cell responses, promotes humoral immune responses, and thereby facilitates the control of persistent virus infection.

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