[(18)F]FDG-PET is highly effective in assessing the activity and the extent of large-vessel vasculitis. Visual grading was validated as representing the severity of inflammation. Its use is simple and provides high specificity, while high sensitivity is achieved by scanning in the state of active inflammation.

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Various Croton species yielded a number of diterpenes which have been found to possess antiulcer (1), anticancer (2), and co-carcinogenic properties (3). Our investigation of Crown megalocarpus, collected from the Chiromo campus of the University of Nairobi, has yielded among other compounds, a novel diterpene belonging to the rare clerodane-type compounds possessing a 9,1O-abeo-CH3 group (1) (4).

The experiments provide evidence for an antiphlogistic effect of irradiation with 5 times 1.0 Gy in vivo. They support the clinical observations of the efficacy of anti-inflammatory radiotherapy.

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Altered fractionated radiotherapy and concurrent chemoradiation could improve local control and survival for patients with locally advanced head and neck cancer. However, intensified treatment seems to increase late toxicity. Late swallowing dysfunction is common and has a large impact on quality of life and can get life-threatening character. Recent studies could show interrelations between the radiation dose to certain anatomical structures involved in the swallowing process and the risk of swallowing dysfunction. Important structures seem to be the pharyngeal constrictors and the supraglottic and glottic larynx. Further prospective clinical validations using standardized diagnostic protocols for dysphagia are necessary to establish dose constraints to anatomical structures involved in swallowing.

PostersPlanta Medica 55(1989) 655 cm whereas cell cultures produce the further methylated artemetin, the other major flavonoid constituents in both the whole plant and cell cultures are similar.