A survey of major urinary proteins (MUPs) from eight BALB/c mouse substrains by isoelectric focusing identified a common pattern with about 10 protein bands in males. One substrain, BALB/cJPt, differed The major urinary proteins (MUPs) of the mouse are a group of 19,000-molecular-weight, structurally and antigenically related proteins with isoelectric points (pls) in the range of pH 4.2 to 4.7. MUPs are synthesized predominantly in the liver but also in salivary, mammary, and other secretary glands. The MUPs produced in the liver are secreted into the plasma and excreted through the kidneys into the urine (9). Normal males excrete 5 to 20 times as much MUP as females. Gonadectomy reduces the quantity of MUP excreted by males to the female level (10). Administration of testosterone induced females and castrated males to excrete levels of MUP characteristic of normal males, indicating the regulatory role of this hormone.A genetic locus originally designated Mup-a (now called
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