The reaction between indole and sodium glyoxylate under basic conditions produces, in addition to the expected sodium 3-indolylglycolate (3a), the 1-substituted derivative (4a). 3a partially condenses with unreacted indole and with 4a yielding the corresponding 3 ,3′-diindolyllmethane derivatives, 5a and 6a. All compounds were isolated and identified as methyl esters.
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