Oxygen is frequently given in the treatment of patients with acute myocardial infarction. The hemodynamic changes associated with its administration in this condition have not been defined.The purpose of this study has been to investigate the effect of breathing oxygen on the cardiac output and systemic arterial pressure of patients in the early stages of acute myocardial infarction. SUBJECTS AND METHODSSix male patients aged 47 to 72 years were studied on the first and second day of myocardial infarction.In two of these there were additional studies on the sixth and seventh days. In one patient there was only one study on the tenth day. All had unequivocal evidence of acute myocardial infarction as judged by the clinical history and electrocardiograph. The clinical data are given in Table I.All patients were investigated in a special intensive care unit permanently equipped with apparatus for observation, investigation, and treatment of patients with acute myocardial infarction (Shillingford and Thomas, 1964). Facilities were available for the measurement of cardiac output and intravascular pressures.After clinical assessment, electrocardiography, and chest radiography were completed, polythene catheters (Intramedic U.S.A. PE60) were inserted percutaneously into the brachial artery and an antecubital vein. The venous catheter was advanced so that the tip lay in the superior vena cava. Heart rates were measured from an electrocardiographic tracing over half-minute periods throughout the study and when cardiac output determinations were made. Cardiac output was measured by a dye dilution technique using Coomassie Blue (I.C.I.) as indicator and recording the curve with a photoelectric earpiece (Cambridge Instrument Co.).The first curve was calibrated by equating the height of the tail of the curve three minutes after injection with the amount of indicator in a central venous or arterial blood sample taken at the same time. Dye was extracted from the plasma and measured by spectrophotometry. Subsequent cardiac outputs were calculated according to the areas of the curves (Gabe, Tuckman, and Shillingford, 1962
No abstract
Oxygen is frequently given in the treatment of patients with acute myocardial infarction. The hemodynamic changes associated with its administration in this condition have not been defined.The purpose of this study has been to investigate the effect of breathing oxygen on the cardiac output and systemic arterial pressure of patients in the early stages of acute myocardial infarction. SUBJECTS AND METHODSSix male patients aged 47 to 72 years were studied on the first and second day of myocardial infarction.In two of these there were additional studies on the sixth and seventh days. In one patient there was only one study on the tenth day. All had unequivocal evidence of acute myocardial infarction as judged by the clinical history and electrocardiograph. The clinical data are given in Table I.All patients were investigated in a special intensive care unit permanently equipped with apparatus for observation, investigation, and treatment of patients with acute myocardial infarction (Shillingford and Thomas, 1964). Facilities were available for the measurement of cardiac output and intravascular pressures.After clinical assessment, electrocardiography, and chest radiography were completed, polythene catheters (Intramedic U.S.A. PE60) were inserted percutaneously into the brachial artery and an antecubital vein. The venous catheter was advanced so that the tip lay in the superior vena cava. Heart rates were measured from an electrocardiographic tracing over half-minute periods throughout the study and when cardiac output determinations were made. Cardiac output was measured by a dye dilution technique using Coomassie Blue (I.C.I.) as indicator and recording the curve with a photoelectric earpiece (Cambridge Instrument Co.).The first curve was calibrated by equating the height of the tail of the curve three minutes after injection with the amount of indicator in a central venous or arterial blood sample taken at the same time. Dye was extracted from the plasma and measured by spectrophotometry. Subsequent cardiac outputs were calculated according to the areas of the curves (Gabe, Tuckman, and Shillingford, 1962
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