Patients with Ki-67 LI >5% had a reduced survival (P< 0.0001) -none survived beyond 86 weeks following diagnosis, whilst 63% of patients with < 5% positive cells were still alive at 100 weeks. The univariate analysis showed that in astrocytomas expression of p53 mutants, EGFR protein, and Ki-67> 5% are associated with malignant progression and poor prognosis. The multivariate analysis revealed that only tumour grade and Ki-67LI were independent prognostic factors for survival.

The authors describe and discuss a case of malignant choroid plexus papilloma originating in the lateral ventricle of an 11-month-old child. Unusual features include a long survival time of 9 years and the presence of an extraneural malignant deposit, probably metastatic in origin.

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Experience with the use of the Kiel bone graft in anterior cervical interbody fusion in cervical spondylosis is reported. The survey reviews the results of operations on 73 disc spaces in 65 consecutive patients, from 2 to 5 years after the operation. We have failed to confirm that any bony fusion in the true sense occurs with Kiel bone in anterior cervical interbody fusion. However, the aims of the operations are achieved, namely removal of the disc and osteophyte, fixation of the spine to prevent compression of the neural tissues, distraction of the adjacent vertebral bodies providing increased room in the intervertebral foramina and stability of the spine.

No abstract