1 Doses of clonidine 0.15 mg or guanfacine 1.0 mg, respectively, and 2 h later additional doses of clonidine 0.3 mg or guanfacine 2.0 mg, respectively, were given to 24 healthy students. 2 Blood pressure was reduced by the same amount by both drugs. 3 Plasma noradrenaline concentrations decreased with both drugs, but the reduction was significantly greater following the administration of clonidine. 4 Mental activity in the EEG was less suppressed in the guanfacine group than in the clonidine group. The differences were statistically significant. 5 Self-estimations for well-being and mood showed only small changes due to guanfacine but significant changes due to clonidine. 6 The decrease of information processing and the increase in reaction time, measured by performance in different psychometric tests, were significantly more pronounced after clonidine treatment than guanfacine. 7 A dose-response relationship could only be observed in vigilosomnograms, in the tests of selfestimation related to well-being and mood and in the decrease in plasma noradrenaline in the clonidine group. 8 It was concluded that guanfacine had a lesser CNS depressant action than clonidine, when administered in equipotent hypotensive doses.
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