Objectives:The aim was to study interaction of aqueous leaf extract of Aegle marmelos (AM) with cholinergic, serotonergic, and adrenergic receptor systems using appropriate rat tissues-ileum, fundus and tracheal chain, respectively.Materials and Methods:Cumulative concentration-response curves (CRC) were constructed at various doses on each tissue for AM and respective standard agonist. The CRC was again plotted in presence and absence of respective standard antagonist to confirm the interaction of receptor system and AM.Results:AM induced concentration-dependent contractions in isolated rat ileum (0.2–6.4 mg/ml) and fundus (0.2–3.2 mg/ml) that were inhibited significantly (P < 0.05) in the presence of atropine (10−7 M) and ketanserin (10−6 M), respectively. The relaxant effect, produced by AM (0.2 mg/ml) on carbachol (10−5 M) precontracted rat tracheal chain, was also inhibited significantly (P < 0.05) by propranolol (1 ng/ml).Conclusion:It may be concluded that AM possesses agonistic activity on cholinergic, serotonergic and adrenergic receptors.
Mahaseth, et al.: Interaction of Psidium Guajava with Receptor SystemThe present study investigates the interaction of aqueous leaf extract of Psidium guajava with muscarinic, serotonergic and adrenergic receptor system using isolated rat ileum, gastric fundus and trachea, respectively. The concentration-dependent contractile response of aqueous leaf extract of Psidium guajava was parallel and rightward of standard agonists, ACh and 5-HT indicating agonistic activity on muscarinic and serotonergic receptor systems. The inhibition of aqueous leaf extract of Psidium guajava mediated contractions in presence of atropine (10 -7 M) and ketanserin (10 -6 M) confirmed the activity. Relaxant effect of PG (0.2 mg/ml) on carbachol induced pre-contracted rat tracheal chain indicated its agonistic action on adrenergic receptor system. Inhibition (P<0.05) of the action in the presence of propranolol (1 ng/ml) confirmed the activity. It may be concluded that PG possesses agonistic action on muscarinic, serotonergic and adrenergic receptor systems.
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