Background:Insulin treated diabetic patients often do not adjust their insulin doses. We developed a method to provide a quantitative and qualitative assessment of this behavior.
Methods:Fourteen patients provided logbook pages of their self-monitoring of blood glucose (SMBG) data and insulin doses. We compared the actual decisions of patients in real-life to what they would decide on the same SMBG, as an a posteriori exercise. We also compared these decisions and those proposed by 6 diabetologists on the same sets of data to the recommendations made by HumaLink, an automated insulin dosage system.
Results:1) Patients in real-life modified their insulin doses least often. However, given a chance to make these decisions a posteriori, they modified their insulin doses more often. HumaLink proposed changes even more often, and diabetologists were the most aggressive in changing insulin doses. 2) The decisions proposed by the patients in real-life or a posteriori and by the diabetologists were compared to the recommendations made by HumaLink, using a decisions analysis grid (DAG). For these three groups, full disagreement with HumaLink (patient or physician increases while HumaLink decreases and the opposite) was observed for less than 5% of the cases. 3) By comparison to HumaLink, patient decisions seemed guided by the desire to avoid hypoglycemia. By contrast, decisions by diabetologists seemed often to be guided by the desire to avoid hyperglycemia.
Conclusion:These methods provide an objective evaluation of insulin dose adjustments by patients with diabetes and may be useful to assess the effectiveness of educational programs.
J Diabetes Sci Technol 2007; 1:3-7
Journal of Diabetes Science and Technology
We report a case of 15-yr-old child that was presented with headache, polyuria,
polydipsia, recent ocular motor and abducens nerve palsies and rapid visual loss. He had a
long history of progressive symmetric muscular weakness predominant in the lower limb
girdle. Water deprivation revealed central diabetes insipidus. Hormonal explorations
demonstrated preserved pituitary function with mild hyperprolactinemia at 21.5 ng/ml (N:
2.6 to 13.1 ng/ml). Magnetic resonance imaging showed an extensive isosignal T1 and
hyposignal T2 enhanced lesion infiltrating the pituitary gland, optic-chiasmal
hypothalamic region, cavernous sinus, cerebrum tent and sphenoid and temporal meningeal
spaces. The serum level of angiotensin converting enzyme and cerebrospinal fluid analysis
were normal. No other systemic localisation was identified. Muscle biopsy objectified
dystrophic changes. Genetic study identified a delT 521 mutation characteristic of
Limb-girdle muscular dystrophy type 2C. Corticotherapy rapidly ameliorated the
neurological symptoms. This patient was diagnosed as having neurosarcoidosis.
Neurosarcoidosis is rarely reported in childhood. We discuss the problems related to
diagnosis in such a situation below.
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