Pregnancy and child birth are common and highly important aspects of women’s life. The focus of midwifery is on the care of essentially healthy women, and the care extends to women with social, medical or obstetric risk factors. A descriptive study to assess the knowledge of antenatal mothers on selected health problems complicating pregnancy was conducted. 100 antenatal mothers were selected through simple random sampling method. Among 100 antenatal mothers, 83% had inadequate knowledge and 17% had moderately adequate knowledge. There was highly significant association between the knowledge of antenatal mothers and their demographic variables such as educational status, occupation, and monthly income. It is reported that many of the antenatal mothers were having poor knowledge of selected health problems complicating pregnancy and its clinical manifestation and risk factors. Hence, it is necessary to create awareness among antenatal mothers which might improve their health seeking behaviors. This can be achieved by giving health education to the antenatal mothers. So the researcher had given instructional manual to improve knowledge regarding selected health problems complicating pregnancy which included iron deficiency anemia, gestational diabetes mellitus and pregnancy induced hypertension.