The preparation of polystyrene−divinylbenzene-supported
derivatives of tris(2-aminoethyl)amine and methyl
isocyanate are described. These polymeric reagents are used to
quench excess reactants and remove known impurities
from the crude reaction products obtained from the solution-phase,
parallel syntheses of ureas, thioureas, sulfonamides,
amides, and pyrazoles. In conjunction with the use of other
polymeric reactants during the course of a reaction, the
addition of polymer-supported quench reagent(s) at the conclusion of
the reaction allows isolation of the desired
product by a single filtration and evaporation of solvent. The
mechanical simplicity and efficiency of this methodology
make possible the rapid, parallel purification of crude reaction
products obtained via solution-phase syntheses, regardless
of whether the intended product is a single compound or a mixture of
compounds, and hence offers an attractive
alternative to solid-phase organic synthesis in the practice of
combinatorial chemistry.
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