This paper elucidates the development of a curcumin cross-linked collagen aerogel system with controlled anti-proteolytic activity and pro-angiogenic efficacy. The results of this study showed that in situ cross-linking of curcumin with collagen leads to the development of aerogels with enhanced physical and mechanical properties. The integrity of collagen after cross-linking with curcumin was studied via FTIR spectroscopy. The results confirmed that the cross-linking with curcumin did not induce any structural changes in the collagen. The curcumin cross-linked collagen aerogels exhibited potent anti-proteolytic and anti-microbial activity. Scanning electron and atomic force microscopic analysis of curcumin cross-linked collagen aerogels showed a 3D microstructure that enhanced the adhesion and proliferation of cells. The highly organized geometry of collagen-curcumin aerogels enhanced the permeability and water-retaining ability required for the diffusion of nutrients that aid cellular growth. The pro-angiogenic properties of collagen-curcumin aerogels were ascribed to the cumulative effect of the nutraceutical and the collagen molecule, which augmented the restoration of damaged tissue. Further, these aerogels exhibited controlled anti-proteolytic activity, which makes them suitable 3D scaffolds for biomedical applications. This study provides scope for the development of biocompatible and bioresorbable collagen aerogel systems that use a nutraceutical as a cross-linker for biomedical applications.
L-arginine hydrochloride monohydrate (LAHCl.H 2 O) has been synthesized and single crystals have been grown from its aqueous solution by slow evaporation and slow cooling methods. The solubility of the material was measured at various temperatures and bulk crystals of size 26x13x11 mm 3 have been grown by optimizing the growth parameters. The grown crystals have been subjected to single crystal XRD studies to confirm the structure and to estimate the lattice parameters. FTIR analysis indicate the mode of vibrations of different molecular groups present in LAHCl and confirm the protonation of guanidyl, amino groups and deprotonation of COO -groups. UV-Vis transmission spectrum revealed the linear optical properties of the grown crystals with a transparency of 65% over the entire visible range upto 300 nm. Thermal behavior of the grown crystal was investigated from DTA and TGA measurements. Dielectric studies have been carried out on the grown crystals. Kurtz and Perry powder SHG technique confirms the NLO property of the grown crystal. The SHG efficiency of LAHCl was found to be 0.38 with respect to KDP.
We report on the growth of a different orientation plane of Ni3TeO6 single crystal by the flux growth method for the first time. X-ray diffraction is used to characterize the single crystal and it crystallizes into the trigonal structure having space group R3 with lattice parameters of a = 5.1087 Å and c = 13.767 Å. The earlier studies reported that the antiferromagnetic (AFM) ordering below T(N) ∼ 52 K confirms to be valid only under high magnetic field. In contrast, the existence of a ferrimagnetic-like ordering due to the antiferromagnetically coupled spins of uncompensated longitudinal staggered moments is revealed from the low field average spin susceptibility data analysis. The spin structure of Ni3TeO6 has been proposed with low magnetic field using single crystal samples. We believe that the Ni ions in the two stacked Ni(I)-Ni(II) and Ni(III)-Te 2D honeycomb ring layers have different spin sizes--the former may have an average moment of S = 3/2 and the latter remains to be S = 1, and the interlayer antiferromagnetic interaction of the ferromagnetically coupled layers leads to the incomplete cancellation below ∼72 K. The ferrimagnetic ordering and the extra paramagnetic spin moment beyond S = 1, observable at low field, can be suppressed with high magnetic field, suggesting the existence of a field-sensitive spin-orbit coupling in Ni3TeO6, that remains to be explored experimentally and theoretically.
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