In entrepreneurship, entrepreneurial exploration and exploitation have been considered central activities for the survival, growth, and renewal of businesses. In this review we systematically examine research on these topics in family business. Our review comprises 59 publications examining exploration and/or exploitation in family firms published between 2001 and 2015 in 32 publications. The article highlights the contributions of family business in this area and reveals additional areas where a stronger connection between these concepts and the family business field could be developed. We suggest several new research directions that may enhance the understanding of these entrepreneurial activities in family business.
SummaryThe relation between the ratio of the natural 12C and 13C isotopes of carbon in the feed and resultant faeces of animals was studied to develop a technique for estimating the proportion of C3 species (tropical legumes) and C4 species (tropical grasses) selected by grazing animals.In general, theδ13C values (see text for definition) of faeces from rabbits, sheep, goats and cattle were lower (more negative) than those of the corresponding feeds by from 0·4 to 2·0. This was possibly due to contamination in the gut by tissues or fluids with lower δ13C values. When C4 and C3 feeds were alternated, cattle took about a week to fully achieve the new level (δ13C of – 28·7 on the C3 feed and – 13·1 on the C4 feed) in the faeces. This time lag is associated with the time taken for the feed to move through the digestive tract.When mixed C3 and C4 feeds were fed to rabbits, sheep, goats and cattle there was a negative linear relation between percentage legume (C3) in the feed and the δ13C of the faeces (P < 0·01). A decrease in one unit in the δ13C value was associated with an increase of 7·0–8·5% legume in the diet.Estimation of the percentage legume in the feed from the δ13C value of the faeces and of the C3 and C4 components of the diet, resulted in a consistent over estimation of the legume component because the faeces had lower values than the corresponding feeds. This bias was removed if the prediction was based on the δ13C of the feeds minus 1 unit; the legume percentage in the diets of the sheep, goats and cattle could then be estimated with a precision of about ± 5%.Differences in digestibility between the C3 and C4 components greatly bias the estimations. This bias in the diets fed to rabbits was effectively removed by using in vitro organic matter digestibility values of the two components to correct for the differences. Legume percentage in the diet could then be estimated with a RSD of ± 3%.Advantages and disadvantages compared with alternative methods of estimating the diet of grazing animals are discussed.
Cattle and goats in Australia lack the ability to totally degrade 3-hydroxy-4(1H)-pyridone, also known as 3,4-dihydroxy pyridine (3,4 DHP), the ruminal metabolite of mimosine, a toxic aminoacid present in the leguminous shrub Leucaena leucocephala. Ruminants in Hawaii have this capacity due to the presence of micro-organisms able to rapidly degrade the DHP. A mixed bacterial population capable of rapidly degrading DHP in vitro was isolated from a goat on the island of Maui. Cultures were grown anaerobically, without added sugars, in Medium 98-5 containing DHP. Cultures at a dilution of 10(-12) from the original rumen fluid were introduced into Townsville and further sub-cultured and multiplied in vitro in strict isolation at the Oonoonba Veterinary Laboratory, Townsville. Infusion of the culture into a goat and a steer fed a 100% leucaena diet resulted in cessation of DHP excretion in the urine. After 60 days the serum thyroxine levels and thyroid size were normal and there were no clinical signs of disease. The ability of the rumen fluid to degrade DHP in vitro showed that the bacteria had become established in the rumen. In the absence of any disease in the animals, clearance has been given for the wider use of these cultures in areas where leucaena is grown. The limited evidence suggests that the leucaena toxicity problem can be solved by the use of these introduced bacteria.
A critical determinant of the efficacy of antineoplastic therapy is the response of malignant cells to DNA damage induced by anticancer agents. The p53 tumor-suppressor gene is a critical component of two distinct cellular responses to DNA damage, the induction of a reversible arrest at the G1/S cell cycle checkpoint, and the activation of apoptosis, a genetic program of autonomous cell death. Expression of the BCR-ABL chimeric gene produced by a balanced translocation in chronic myeloid leukemia, confers resistance to multiple genotoxic anticancer agents. BCR-ABL expression inhibits the apoptotic response to DNA damage without altering either the p53-dependent WAF1/CIP1-mediated G1 arrest or DNA repair. BCR-ABL-mediated inhibition of DNA damage-induced apoptosis is associated with a prolongation of cell cycle arrest at the G2/M restriction point; the delay of G2/M transition may allow time to repair and complete DNA replication and chromosomal segregation, thereby preventing a mitotic catastrophe. The inherent resistance of human cancers to genotoxic agents may result not only by the loss or inactivation of the wild-type p53 gene, but also by genetic alterations such as BCR-ABL that can delay G2/M transition after DNA damage.
SUMMARYSeveral models have been proposed in the literature relating gain per animal (Ya) and stocking rate (x) from grazing experiments. Results from an experiment in which tropical pasture species were grazed continuously by beef cattle at a number of stocking rates (Jones, 1974) were used to examine this relation. A simple linear model of the form y = a − bxfitted the data well. Production per hectare (Yh) was related to stocking rate by yh = ax − bx2.Stocking rate for maximum gain per hectare (the optimum stocking rate) on each pasture could be calculated from the linear regression by a/2b.Data from a number of stocking rate experiments in tropical and temperate environments were examined to see if this relation held for a wider range of stocking rates and pasture types. Results were expressed on a common basis by calculating the optimum stocking rate and relating ratios of gain to ratios of stocking rate relative to that at the optimum.For gain per animal, the overall relation obtained: Ya = l·999–0·999x (r = –0·992; P < 0·001; n = 114) did not differ significantly from the expected linear relation: y = 2−x. Linearity was established over the range 0·18–2·0 times the optimum stocking rate. At rates greater than twice the optimum, animal gain was negative. When expressed as gain per hectare (Yh) the quadratic equation Yh = 2x − x2 gave a good fit to the data over this range.It is suggested that, since the relation between production per animal and stocking rate (animals/ha) remains linear over a wide range of stocking rates, two rates of stocking (with replication) may be adequate for grazing experiments and these would not have to span the optimum stocking rate in order to predict gain at the optimum stocking rate.
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