Bowel-associated dermatosis-arthritis syndrome (BADAS) is a rare and recurrent neutrophilic dermatosis condition. Due to the rarity of this syndrome and the difficulty of the disease recognition and management, there was no clear reported incidence rate of this syndrome. 20% of patients after ileojejunal bypass surgery for morbid obesity were reported, by Jorizzo et al., to have BADAS. The underlying etiology of BADAS is not fully understood; therefore, the diagnosis of this condition is difficult and the approach for the management as well. Herein, we report a case of BADAS with unusual musculoskeletal presentation.
Background: Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. The study aimed to observe levels the Preptin, Lactate dehydrogenase (LDH), Fasting Blood glucose (FBG). Methods: Serum Preptin, LDH and FBG levels were determined in 50 patients with acute myocardial infraction , 50 patients with (type 2 diabetes with myocardial infraction) and 50 healthy subjects. Results: The results show a significant increase in the concentration of serum (Preptin, LDH and FBG) in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p?0.05). But it was found no significant deference in the concentration of serum Preptin and FBG between (AMI and controls) groups (p?0.05). Also it was found no significant deference in the concentration of serum LDH between (AMI with T2DM and AMI) groups (p?0.05). Conclusion: Assessment of preptin with lactate dehydrogenase and fasting glucose may predict pancreatic as well as cardiac dysfunction and its helpful in stratification of severity risk.
Tuberculosis (TB) is a leading cause of death among people with HIV. In 2009, there was an estimate of 380,000 deaths due to TB among HIV patients. 78% of TB/HIV co-infection cases reside in sub-Saharan Africa; HIV prevalence is as high as 80% in some countries. Therefore, the prevalence of HIV infection in the study population of TB was determined. Clinical, laboratory and radiological presentation of TB were analyzed and compared between HIV sero-ve and HIV sero + ve patients. Observational case-finding hospital-based study was done on 60 TB patients, performed in 3 hospitals in Sudan. Interview-based questionnaires and medical records were used for data collection. Prevalence of HIV-infected TB patients among the study population was 16.7%. The study revealed that 50% of the HIV+ve TB patients were younger than 30 years. There was no major sex difference between HIV+ve and −ve TB patients (P=0.905). However, males were predominant among the whole study population of TB patients. 60% of HIV+ve patients originated from the north, whereas the origins of the HIV-ve patients were more or less equally distributed (P=0.012). Clinical presentations of HIV+ve and −ve TB patients were similar and the differences were not statistically significant. When comparing the lab findings;+ve sputum smear was found more common among HIV+ve patients (70% vs. 54%) and a+ve PPD test was also more common among HIV+ve patients (75% vs. 50%). A clear CXR was the only statistically significant difference between the two groups, being more common in HIV+ve (40% vs. 6%) (P=0.002). The study concluded that the prevalence found was low in comparison to most of the countries in the region but high in comparison to developed countries. The main differences between HIV+ve and −ve was a+ve sputum smear, +ve PPD test, and a clear CXR, all of which were more common in HIV+ve TB patients. Therefore, the TB/HIV programme should be strengthened; starting by knowing the exact incidence of TB/HIV among the population, implementing better diagnostic tools and more researches to be conducted on a larger scale
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