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SUMMARY1. Differences in Na transport between skins from Rana temporaria and R. esculenta maintained for up to several weeks in water or 0 7 % saline (0-7 g NaCl in 100 ml. H20), with and without daily injections of 4% saline (4 g NaCl in 100 ml. H20), were measured, in vitro.2. In saline-treated skins, the following changes were found: (a) An increased Na content. (d) A highly significant fall in Na influx, accounting for the reduced I8C; a small reduction in Na efflux was not significant, statistically.(e) The Pitressin-induced increment in I., was usually considerably lower compared with that in water-exposed skins; considered relative to the pre-Pitressin values, however, there were no clear differences.(f) By calculation from the changes in resistance (R) caused by replacement of outer Na2SO4 Ringer by K2S04 Ringer solution, I. Eo, the electromotive force of the active sodium transport system, was moderately, but significantly, reduced, II. R shuntt the shunt path resistance, was moderately, but significantly, increased, and III. Rser' the series path resistance, was considerably, and highly significantly, increased.(g) K influx from outer K2SO4 Ringer solution was reduced. 3. Differences between skins from water-exposed and saline-treated frogs persisted, in vitro, despite the occurrence of anionic-dependent acute changes after mounting in Ringer solution.4. There were seasonal changes in 1,, and in the effects of saline treatment.R. HORNB Y AND S. THOMAS 5. The findings are discussed in terms of decreased permeability of outer barriers to ion-diffusion, and reduced activity of a Na pump.

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The combination of captopril and hydrochlorthiazide was assessed in 15 hypertensive patients in a general practice setting. The first aim was to determine whether the fall in blood pressure, noted after the first dose of an ACE inhibitor given alone, became unacceptable when the drug was given with a diuretic. The second aim was to assess the impact of the ACE inhibitor on the biochemical abnormalities associated with thiazide diuretic therapy. The drug combination markedly reduced blood pressure but not below 110 systolic after the first dose. In the long-term the treatment significantly lowered blood pressure but did not produce any significant or clinically relevant changes in serum chemistry.