To analyze RA patients treated with biologics in a University Hospital. Proportion of patients treated with different drugs, as first, second or third choice. To know the disease activity before and after biologic therapy. To know side effects and the reasons.
EWRR abstracts seen histologically, but synovial IL-1, IL-6 and TNFa gene expressions were markedly decreased at day 1. The inducible promoters all showed a different activation profile during the course of inflammation, meaning they all react differently during the disease process. The Saa3 promoter showed the highest upregulation (120 fold) and was the only promoter which showed an early peak in activation at day 1 after arthritis induction, resembling neutrophil influx. Conclusions Effects of IL-10 were seen on PG depletion and gene expressions, therefore IL-10 can be a feasible therapeutic protein to modulate SCW arthritis. On the other hand, the Saa3 promoter seems to be the best candidate for local intra-articular gene therapy with the use of disease-inducible promoters, because it showed a high and quick upregulation during disease activity. Hence, combining the Saa3 promoter with the therapeutic protein IL-10, can be a promising combination to modulate an acute model of arthritis using disease regulated gene therapy.
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