with Pathological Report and References to the Literature on Kindred Cases, by CUTHBERT LOCKYER, M.D. THE subject of the following notes was the daughter of a woman who died of consumption at the age of 28 and of a man who died of cancer at the age of 68. She married when she was 19 years old, and had a miscarriage four months later. Subsequently she had three children, the youngest being born when she was 32. After that time means were taken to prevent conception, and the patient's periods were regular until March, 1901, when her age was 40. Up to Xmas, 1900, her health was good, but she then began to lose flesh rapidly. On February 17th, 1901, coitus was effected without any precautions against conception being employed, and the patient positively stated that this waa the only occasion on which conception could have taken place. After that date a period was missed, and on April 9th there was a severe hemorrhage from the uterus on account of which Dr. Malcolm Mackintosh was consulted. After five
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