CN OH O Ar NH 2 R' R Ar-CHO R + + TiCl 4 r.t 1 2 3 4a-tThree component coupling of one pot reaction which servers as the most convenient route to the synthesis of benzopyran derivatives using the TiCl 4 catalyst (10 mol %) under solvent free conditions is described. The procedure offers a systematic method with a number of advantages including operational simplicity, neat reactions, reduced reaction time, high yields of products and applicability to large scale reactions.
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Synthesis and Biological Evaluation of 3-Substituted-4-[2'-(4"isobutylphenyl)propionamido]-5-mercapto-1,2,4-triazoles and Their Derivatives.-A variety of the title 5-mercaptotriazoles (III) (15 examples) are synthesized and converted into S-alkyl derivatives (V) and triazolothiadiazoles (VI). Some of the compounds obtained show promising antimicrobial and antiinflammatory activities. -(UDUPI, R. H.; SURESH, G. V.; SETTY, S. RAMACHANDRA; BHAT, A. R.; J. Indian Chem.
12 examples) are prepared in good to high yields and tested for their antitubercular, antibacterial and antifungal activities. -(UDUPI*, R. H.; KULKARNI, V. M.; PURUSHOTTAMACHAR, P.; SRINIVASALU, N.; J. Indian Chem.
Oral route of drug administration has wide acceptance and hence up to 50-60% of total dosage forms are administered orally. Solid dosage forms like tablets and capsules though popular but has certain limitations like difficulty in swallowing, risk of choking in the throat and always require some fluid to consume. This difficulty in swallowing or dysphasia is currently affecting 35% of general population 1. Due to this problem, pediatric and geriatric patients, tend to avoid taking oral solid dosage forms like tablets and capsules due to fear of choking 2 .
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