Keywords: in vitro; in vivo; skin hydration; vital moisture cream; vitamin E release ratio; water-soluble chitosan SynopsisThe effects of the addition of water-soluble chitosans on skin hydration, physico-chemical properties and vitamin E release ratio of vital moisture creams (vitamin E-containing creams) were studied. Results show that vitamin Econtaining creams containing different molecular weights and/or concentrations of water-soluble chitosans are pseudoplastic fluids. The apparent viscosity of vitamin E-containing creams increased with increasing molecular weight and/or with increasing concentration of water-soluble chitosans used in the formula. The apparent viscosities of those vitamin E-containing creams containing 0.5% water-soluble chitosan were higher than those containing 2% glycerol monostearate (control). The higher apparent viscosity of vitamin E-containing creams obtained using water-soluble chitosans improves the stability and enhances skin hydration of the creams thus prepared. Such creams containing water-soluble chitosans were stable for more than 3 months during high temperature or cyclic temperature storage, whereas those containing glycerol monostearate had a shorter storage life of 2 months. Skin hydration in terms of water-holding capacity of vitamin E-containing creams containing 1.0% water-soluble chitosan was superior to those containing 2% glycerol monostearate. No erythema occurred on shaved rabbit skin after applying vitamin E-containing creams containing water-soluble chitosans, and the vitamin E release ratios of these creams were similar to the cream containing 2% glycerol monostearate. Re sumeÂNous avons e tudie le roà le de l'addition de chitosanes hydrosolubles dans une creÁ me hydratante vitale, sur le taux de relargage de vitamine E, l'hydratation de la peau et les proprie te s physiscochimiques de cette pre paration. Les re sultats montrent que les creà mes hydratantes vitales contenant diffe rentes masses mole culaires et/ou concentrations de chitosanes hydrosolubles sont des fluides pseudo-plastiques. La viscosite apparente des creà mes hydratantes vitales croit avec la masse mole culaire et/ou la concentration des chitosanes employe s dans la formulation. La viscosite apparente de ces creÁ mes hydratantes vitales contenant 0.5% de chitosane hydrosoluble est supe rieure aÁ celle contenant 2% de monoste arate de glyce rol (controà le). La viscosite apparente plus e leve e des creà mes hydratantes vitales obtenue graà ce aÁ la pre sence de chitosane hydrosoluble ame liore la stabilite , accroit l'hydratation de la peau. Les creà mes hydratantes vitales contenant du chitosane hydrosoluble sont stables pendant 3 mois au cours d'un stockage aÁ tempe rature e leve e, en continu ou cyclique. Ceux contenant du monoste arate de glyce rol ont une dure e de conservation infe rieure, de 2 mois. L'hydratation de la peau, en terme de capacite de re tention d'eau, pour les creà mes hydrantes vitales contenant 1% de chitosane hydrosoluble sont supe rieu...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.