Can people's feelings about harm (i.e., their hedonic reactions) lead them to be morally condemned, even if they do not cause the harm themselves? We show that individuals who experience pleasure at serious harm that has befallen another person are judged both immoral and evil. This effect occurs for harm-causing actors, and for observers who play no role in causing the harm; actors can also be judged as immoral and evil when they experience mere indifference (Study 1). Observers are more likely to be similarly judged when they experience direct rather than indirect pleasure from harm caused to another (Study 2). The effects of pleasure are dissociable from those of malevolent desires (Study 3). Targets' experience of pleasure at the harm caused to another person leads to the social exclusion of observers (Studies 1-3) and the harsh punishment of actors, including the death penalty (Studies 1, 4a, and 4b).
Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-1417, IM twice a day for 1 month in an open-label trial, produced no objective improvement of strength in nine patients with ALS. No patient entered the double-blind, placebo-controlled phase of the trial.
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