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The results reported here demonstrate that hDAF transgenic pig hearts are not hyperacutely rejected when transplanted into baboon recipients. Orthotopically transplanted transgenic pig hearts are capable of maintaining cardiac output in baboons. An optimum immunosuppressive regimen is the subject of ongoing research.

Holstein calves (159) were assigned alternately to one of seven regimens through, day 45: nurse dam for 12 to 24 h, dam's milk to 96 h, milk replacer with all milk protein; low (less than or equal to 45 mg/ml) immunoglobulin colostrum to 96 h, then either colostrum, replacer with all milk, or soy protein; high (less than 60 mg/ml) immunoglobulin colostrum to 96 h, then replacer all milk; replacer all milk protein from birth; or saleable milk from birth. Colostrum immunoglobulin was estimated by colostrometer and colostrum was frozen. Starter and water were offered free choice on day 5. Calves deprived of colostrum gained poorly and suffered severe and long scour episodes and high mortality. No differences of body weight gains were observed between calves that nursed compared with those hand fed. Calves fed colostrum with high immunoglobulin gained weight from birth to day 4 while those fed low lost weight. Overall severity and duration of scours were less for calves fed colostrum with high compared to low immunoglobulin. Calves fed undiluted colostrum (5 to 45 days) had more severe scours longer than those fed milk replacer. Serum protein and immunoglobulin were higher for calves hand fed high immunoglobulin compared to low immunoglobulin colostrum or nursing at 12 to 24 h and 4 days after birth. A positive relationship developed between serum protein and immunoglobulin at 12 h to 24 h, 4 and 11 days. Mortality was low for all calves receiving colostrum.

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