R.F. Thierry scite author profile

The feasibility was studied of in situ hybridisation using chromosome specific DNA probes on paraffin wax embedded normal and malignant tissues from different organs. Both isolated nuclei and 5 .m sections were used in in situ hybridisation experiments with biotinylated repetitive DNA probes specific for the centromeric regions of chromosomes 1 and 17. The hybridisation results were visualised with peroxidase-diaminobenzidine. The optimal pretreatments with sodium thiocyanate and pepsin were experimentally defined for the different tissues.Although

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4 Detection of chromosomal aberrations in tissue sections of solid tumors by in situ hybridization

Thierry¹,

Devilee²,

Smit³

et al. 1989

Cancer Genetics and Cytogenetics

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R.F. Thierry

90 Detection of chromosomal aberrations in interphase nuclei from human primary breast tumors using in situ hybridization with chromosome-specific repetitive DNA-probes

Feasibility of in situ hybridisation with chromosome specific DNA probes on paraffin wax embedded tissue.

4 Detection of chromosomal aberrations in tissue sections of solid tumors by in situ hybridization

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