Immunotherapy with interferon and transfer factor has been tried in 2 cases of Kaposi’s sarcoma of the Mediterranean type, without visceral involvement. Clinical benefits appeared almost worthless and biological data hardly improved. On the contrary, side effects such as leucopenia, malaise, mental confusion proved quite impressive. From these 2 observations it might be concluded that interferon is not the treatment of choice of Kaposi’s sarcoma. Transfer factor, much more easy to use, displayed transient efficacity in 1 patient. Fundamentals about Kaposi’s sarcoma and interferon are reviewed.
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