The cephalosporin derivatives cephradine, cephalexin, cefaclor, and cefadroxil form complexes with bnaphthol, provided water is present. The crystal structures of these complexes have been determined by single-crystal X-ray diffraction. The complexes appear to be inclusion compounds of the clathrate type. In all cases, the cephalosporin molecules play the role of host, while bnaphthol is the guest molecule. Water molecules, which are accommodated in the crystal, play an essential role in the interaction between the guest and host molecules. Cephradine, cephalexin, and cefaclor form isomorphous complexes with b-naphthol, whereas cefadroxil crystallizes in a different morphology. The crystal structures are described in detail and discussed in terms of hydrogen-bonding, van der Waals and electrostatic interactions. The structure of the cefadroxil complex is basically different from that of the other three complexes, although there are notable structural similarities.
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