Research in spine surgery has proposed new soft and less invasive techniques. These are the results of our experience with oxygen-ozone therapy, which we could experiment within the Italian National Health System over 3 years. A total of 1,920 patients were admitted on the basis of unselected enrolment because of lumbosciatic pain. Patients were divided into three groups: (A) Patients with degenerative disc disease and arthropathy: 509 (26.5%), (B) Patients with failed back surgery syndrome (FBSS): 1,027 (53.489%), and (C) Patients with pure herniated lumbar disc: 384 (20%). The rationale of the treatment for all these different pathologies we have taken into consideration is the biochemical mechanism by which they can engender pain and dysfunction. Treatment for group A: paravertebral injection and phleboclysis (two cycles of 6 sessions, one each 3 days) +endoscopic neurolysis. Treatment for group B: paravertebral injection and phleboclysis (two cycles of 6 sessions, one each 3 days) + endoscopic neurolysis with intradiscal procedure (named percutaneous peridurodiscolysis). Treatment for group C: paravertebral injection (two cycles of 6 sessions, one each 3 days) + percutaneous discolysis.The perceived quality of result for this minimally invasive procedure makes oxygen-ozone therapy an interesting weapon in the hands of doctors. Furthermore, if the technique loses its clinical effectiveness, it can be repeated without harm for the patient, and costs for the health organization are notably very low, above all if compared to surgical procedures.We underline the need that this treatment should be performed in protected structures, in operative rooms, under anesthesiologic control, and in the hands of specialists.

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This work presents results of our experience with oxygen-ozone therapy, which we could experiment inside the Italian National Health System through 3 years. A total of 1920 patients were admitted to our evaluation on the basis of unselected enrollment because of lumbosciatic pain. Patients were divided in three groups: (A) Patients with degenerative disc disease and arthropathy: 509 (26.5%), (B) Patients with failed back surgery syndrome (FBSS): 1027 (53.489%), and (C) Patients with pure herniated lumbar disc: 384 (20%).The perceived quality of result makes oxygen-ozone therapy a useful weapon in the hand of the doctors.

Foot ulcers result in substantial morbidity, reduced quality of life, and increased mortality in patients with diabetes. The risk of these ulcers becoming chronically infected is well above 60%. About 50% of patients undergoing non-traumatic lower limb amputations have diabetes. These patients have a high mortality following amputation, ranging from 39% to 80% at 5 years. Some developments have been made towards the treatment of this complication with surgical intervention, topical antiseptics, and systemic antibiotic therapy; however, outcomes continue to remain poor and lead to limb amputation in 15% to 20% of patients within 5 years of the time of initial infection. As an additional alternative, topical ozone therapy could be done by following the main steps: hydrate and start the debridement of the lesion with ozonized water to enable the penetration of the ozone oxygen mixture. Afterwards, start the bagging with the gas mixture, beginning with high concentrations, more frequently in the initial phases, and reduce as the process proceeds. The water or oil prepared with ozone can be useful to control infection inside the wound and accelerate the metabolism in surrounding soft tissues. Therefore, facilitate healing. The patient can thus underwent conservative surgery for removing the necrotic area or osteomielitys. No side effects have been noticed during treatment. Neither allergies nor skin dermatitis were found and frequently the utilization of this therapy shortened the healing period.