Two double-blind between-patient comparisons of the analgesic activity of orally administered pentazocine 50 mg, dihydrocodeine 60 mg and placebo are described, which involved 99 patients in "severe" or "moderate" pain, mainly of skeletal origin, and 103 patients in "severe" or "moderate" pain predominantly of postoperative origin. In both studies pain was assessed by a single observer prior to and 1 hour after the administration of a single dose of one of the test preparations. Both active drugs were significantly superior to placebo, and in both studies a firm trend showed pentazocine to be more effective than dihydrocodeine which was in turn more effective than placebo. Drowsiness more commonly followed pentazocine administration, but nausea and vomiting more commonly followed dihydrocodeine.
Summary
An unusual case of transitional cell carcinoma of the male urethra is presented. The commoner squamous‐cell types are discussed.
The usual zetiological factors, urethral stricture, or seedlings from papillomatous tumours higher in the urinary track are considered in relation to this case and are not found pertinent.
When the patient was seen originally there was no evidence of stricture, but as he was not submitted to urethroscopy the possibility that he may have had a patch of submucous infiltration cannot be excluded.
The symptoms and signs are discussed; the patient presented with gangrene of the penis.
Diagnosis was made by palpation of an indurated swelling which failed to resolve with penicillin. Urethroscopic confirmation was technically impossible.
Treatment was by radical amputation of the penis and the construction of a perineal urethra.
The patient is being kept under surveyance in order that block dissection of the inguinal glands may be undertaken should they become involved by metastatic spread.
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