potential of filling this need because of structures are different from those of the more studied and their those of the more action may too very likely differ. [1] In this growing interest, many of the Phytochemical bioactive compounds from a medicinal plants have shown many pharmacological activities. [2,3] Screening of various bioactive compounds from plants has lead to the discovery of new medicinal drug which have efficient protection and treatment roles in against various diseases. [4] The rapid emergence of multiple drug resistance strains of pathogens to current antimicrobial agents has generated an urgent intensive for new antibiotics from medicinal plants. Many medicinal plants have been screened extensively for their antimicrobial potential worldwide. [5,6] Endophytic fungi are relatively unexplored producers of metabolites useful to pharmaceutical and agricultural industries. [7] Endophytes are the microorganisms that grow inside the plants; both
In the present study, Penicillium species extract isolated from Calophyllum apetalum was used for the synthesis of silver nanoparticles and it was confirmed by changing the color of the silver nitrate UV–Vis spectrum. The synthesized nanoparticles have been characterized by biophysical techniques such as scanning electron microscopy and x-ray diffraction.
The aim of this study is to investigate in vitro antioxidant activities and the phytochemical screening endophytes. Seven different endophytic fungi were isolated from different parts of the plant and their extracts subjected to know antioxidant properties and phytochemical screening. Phytochemical analysis revealed the presence of tannins, flavonoids, steroids, alkaloids, phenols and proteins from different solvents extracts of different endophytes. The antioxidant activity was evaluated by six separated methods: scavenging of free radical DPPH, FRAP, TBA, superoxide radical, FTC and iron methods. All seven different endophytes yielded almost all phytochemicals in methanol extracts which were tested. The endophytes A. niger, Penicillium sp. and Trichoderma sp. have shown potential in vitro antioxidant activities. Further work is needful to isolate the exact compound which is responsible for antioxidant activity and biophysical characterization will be done in the future.
The present study was aimed to evaluate the genotoxic potential of polyherbal formulations by chromosomal aberration test. Cancer being the second most cause of death among all ailments even after the improvised medications needs alternative sources of treatment. Herbal sources were always among the one as prime treatment sources. Polyherbal formulations were taking the lead in medications because of their broad spectrum of activity and synergic effects. Annona squamosa, Zingiber Officinalis, and Triticum Aestivum formulation with 1:2:3 ratio has shown significant results in the definitive and confirmatory chromosome aberration assays. Indicated the test article PF3 did not induce a statistically significant increase in the percentage of cells with aberrations both in the presence and absence of metabolic activation. PF3 was found non-clostagenic at a maximum dose of 15 µg/ml in the CHO cell line. Inhibition of chromosomal aberration, DNA fragmentation, and maintenance of cellular integrity may prevent the genotoxic effect. Further optimization and in vivo authenticated studies need to be proven.
Cancer is the second deadliest cause among all ailments even after the development of modern research and technologies. This leads in search of alternative sources of treating cancer. Herbal formulations were considered to be the rich sources of treating agents for most of the ailments from agelong days. Bacterial Reverse Mutation method of evaluation is one among the preliminary phase incorporated to assess the mutagenic potential of herbal formulations. The selected Polyherbal Formulation (PF3) of Annona Squamosa, Zingiber Officinalis, and Triticum Aestivum in 1:1:1 ratio was evaluated for its mutagenic potential. The results with method I - Plate incorporation and method II - Preincubation indicate that, the PF3 extract at a maximum dose of 5 mg/plate did not cause a positive increase in the mean number of revertant colonies per plate with any of the tester strains either in the presence (+S9) or absence of metabolic activation (-S9). The rich flavonoids and other phytoconstituents of the formulation may be responsible for antimutative properties with the possible inactivation of mutagens or by interfering in the process of mutagenisis. The higher studies were needed to be proven further to authenticate the mutagenic potentialities.
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