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(10-3 M) had no effect on responses to quisqualate (10-i M) and only slightly reduced responses to kainate (10-4 M). Mecamylamine (10-3 M) was ineffective against both agonists.5 In adult rat hippocampal slices, chlorisondamine depressed NMDA receptor-mediated synapticallyevoked field potentials, but again only at high concentrations (10-4-1O-3 M). Synaptic responses that were mediated by non-NMDA excitatory amino acid receptors were less affected. 6 In rat isolated superior cervical ganglion, electrically-evoked synaptic transmission was reduced 1 h after acute in vivo administration of chlorisondamine (0.1 mg kg-1, s.c.

Long periods of Benzodiazepine use are frequent among Quebec elderly. The evidence of increasing dose, particularly for older women, and long-duration of use has important implications for clinicians.

Mechanisms affecting the risk of falls differ across benzodiazepines, and may include cumulative effects of use in the previous few weeks. Thus, benzodiazepine-specific analyses that account for individual patterns of use should be preferred over simpler analyses that group different benzodiazepines together and limit exposure to current use or current dose.

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