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MYC protein expression detected by immunohistochemistry using a commercially available antibody correlates with MYC gene translocation, and could be used as a screening tool to select those cases in which confirmatory genetic testing is mandatory.

The clinical use of lasers in surgery began in 1973 with applications of the carbon dioxide laser in otolaryngology, and since then the use of lasers has become commonplace in many medical and surgical specialties. Nonetheless, when biological tissue is subjected to laser radiation, the target cells can be vaporized, resulting in the aerosolization of their contents and the subsequent exposure of health care workers to laser-generated air contaminants (LGACs). The purpose of our analysis was to summarize and present all of the published literature pertaining to the laser-induced plume chemical and physical composition, health effects, and methods of control. The objective was to identify knowledge gaps within exposure science to set a research agenda for the protection of health care personnel exposed to LGACs. A literature search was performed using the PubMed database using a variety of search strategies and keyword combinations. To locate additional studies, we systematically searched the reference lists of all studies identified by our search, as well as key review papers. To date, researchers have identified roughly 150 chemical constituents of plume, as well as fine and ultrafine particulate matter, which has been shown to include viable cellular material, viruses, and bacteria. However, very few studies have attempted to characterize the effects of laser system type, power, and tissue treated, as it relates to LGAC exposure. Furthermore, current control strategies do not appear to be adequate in preventing occupational exposure to LGACs.

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Less than half of our patients participated in the telemedicine study. However, those who completed the study had confidence in the system, a high degree of satisfaction with the tools and positive behavioral changes.

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This work analyses different refrigeration architectures for commercial refrigeration providing service to medium and low temperature simultaneously: HFC/R744 cascade, R744 transcritical booster, R744 transcritical booster with parallel compression, R744 transcritical booster with gas ejectors, R513A cascade/R744 subcritical booster, and R513A cascade/R744 subcritical booster with parallel compression. The models were developed using compressor manufacturers’ data and real restrictions of each system component. Limitations and operating range of each component and architecture were analysed for environment temperatures from 0 to 40 °C considering thermal loads and environment temperature profiles for warm climates. For booster systems, cascade with subcritical booster with parallel compression provide highest coefficient of performance (COP) for temperatures below 12 °C and above 30 °C with COP increases compared basic booster up to 60.6%, whereas for transcritical boosters, architecture with gas ejectors obtains the highest COP with COP increases compared to the basic booster up to 29.5%. In annual energy terms, differences among improved booster systems are below 8% in the locations analysed. In Total Equivalent Warming Impact (TEWI) terms, booster architectures get the lowest values with small differences between improved boosters.

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