Several preparative resolutions of 5,5-disubstituted hydantoins have been achieved via fractional crystallization of diastereoisomeric salts. The process can be extended by making use of the difference between the variation of solubilities of the hydantoins and their salts with a-methylbenzylamine as a function of the alkalinity of the medium. Optimization for each resolution procedure involves a refinement of the excess amount of base needed. 0 1992 Wiley-Liss, Inc.
Five salts of (±)-fenfluramine (F) and three salts of (±)-norfenfluramine (N) have been identified as being conglomerates. Six of these salts could be resolved by preferential crystallization.
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