SummaryThe production of (S)-ethyl 3-hydroxybutyrate (2) from ethyl acetoacetate (1) in higher yields and with higher optical purity than with the usual procedures was achieved by continuous addition of the substrate 1 and sucrose to an aerated suspension of bakers' yeast. The microbial reduction of 1 by the fungus Geotrichum candidum LINK yields -for the first time -the antipode 3.
Die Gewinnung des Hydroxybutyrats (I) aus Acetessigester in höheren Ausb. und höherer optischer Reinheit als bei den üblichen Darstellungsverfahren gelingt durch kontinuierliche Zugabe des Substrates (II) und Sucrose zu einer mit Luft versetzten Suspension von Bäckerhefe.
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