Traumatic brain disease (TBHD) is a pathological process triggered by the damaging effect of mechanical energy on the brain and is characterized — with a variety of clinical forms — by the unity of etiology, pathogenetic and sanogenetic mechanisms of development and outcomes.
Изучена структура когнитивных расстройств у 72 больных — 38 (I группа) с симптоматической эпилепсией и 34 (II группа) с идиопатической эпилепсией, средний возраст которых составил 48 ± 25,3 года. Показано, что у больных с различными формами эпилепсии могут встречаться когнитивные нарушения, частота и выраженность которых зависит как от типа судорожных припадков, так и от вида и длительности приема антиэпилептических препаратов. Показано, что симптоматическая и идиопатическая формы эпилепсии имеют ряд различий по нейропсихологическим показателям.
We studied 52 patients with epilepsy with the average age of 36.2±14.7 years old. Of them, 38 patients had idiopathic epilepsy, 14 patients had symptomatic epilepsy. Our study has shown that epilepsy is accompanied with increased levels of autoantibodies to NF-200, GFAP, S100, MBP, DNA, GABA and dopamine receptors, testifying to the important role of autoimmune disturbances in the pathogenesis of epilepsy. More severe attacks are accompanied by worsening of neuroimmune dysregulation. The degree and duration of autoimmune process can serve additional diagnostic and prognostic criteria for epilepsies.
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