Intraosseous needle insertion is used as a temporary measure when intravascular access cannot be achieved through peripheral or central venous routes. The intraosseous needle may remain in situ for 72 to 96 hours, but it is best removed within 6 to 12 hours, as soon as an alternative site of intravascular access has been established. The intraosseous route provides fast and reliable vascular access in emergency medical situations. The use of the appropriate technique will ensure that the procedure is performed as safely and effectively as possible.
Five platinum pyridin-2-ylcarboxaldimine complexes of the type cis-[PtCl 2 (2-C 5 H 4 NCH=NR)] (R = CH 2 CH 2 OH (1); R = N(CH 2 CH 2 ) 2 O (2); R = C 6 H 5 (3); R = 1-C 10 H 7 (4); R = (CH 2 ) 8 CH=CH(CH 2 ) 7 CH 3 (5)) were prepared and their in vitro reactivity towards a 20-base pair (single-and double-stranded) DNA determined using nuclease digest studies and RP-HPLC. Variation of the imine functionality allowed for the design of compounds with different physical and chemical properties. Complexes 1 and 3 showed binding to both single-and double-stranded DNA comparable to that of cisplatin (cis-[PtCl 2 (NH 3 ) 2 ]). Crystals of 1 were monoclinic, space group P2(1)/n, a = 9.6612 (15), b = 12.9678 (19), c = 9.7004(13) Å, β = 117.73(3)°, Z = 4. Résumé : On a préparé cinq complexes de pyridin-2-carboxaldimine et de platine du type cis-[PtCl 2 (2-C 5 H 4 NCH=NR)] (R = CH 2 CH 2 OH (1); R = N(CH 2 CH 2 ) 2 O (2); R = C 6 H 5 (3); R = 1-C 10 H 7 (4); R = (CH 2 ) 8 CH=CH(CH 2 ) 7 CH 3 (5)) et, faisant appel à des études de « RP-HPLC » et de digestion par une nucléase, on a évalué leur réactivité in vitro une molécule d'ADN à vingt paires de bases (à simple et à double brin). La variation de la fonction imine a permis de mettre au point des composés ayant des propriétés physiques et chimiques différentes. La fixation des complexes 1 et 3 à l'ADN à simple et à double brin semble être comparable à celle du cisplatine, cis-[PtCl 2 (NH 3 ) 2 ]. Les cristaux du composé 1 sont monocliniques, groupe d'espace P2(1)/n, avec a = 9,6612(15), b = 12,9678(19) et c = 9,7004(13) Å, β = 117,73(3)°et Z = 4.
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