In the title compound, the cyclooctene ring adopts a twist chair–chair conformation. No directional interactions could be identified in the crystal and the packing is governed by van der Waals interactions.
In the title compound, C39H38N2O4, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by 0.3304 (1) and with the methylene C atom adjacent to the octahydroindolizine unit deviating by 0.444 (3) Å from the mean plane defined by the other four atoms. In the octahydroindolizine system, the pyrrolidine ring exhibits an envelope conformation, with the fused methyne C atom deviating by 0.6315 (1) Å from the mean plane defined by the other four atoms, and the piperidine ring exhibits a distorted chair conformation, as reflected in the puckering parameters Q = 0.568 (4) Å, θ = 1.5 (4) and ϕ = 161 (16)°. In the crystal pairs of weak C—H⋯O interactions form centrosymmetric dimers, which are further connected by C—H⋯π interactions. The crystal studied was a non-merohedral twin, with a domain ratio of 0.91:0.09.
In the title compound, C19H16N2O6S, the pyrrolidine ring adopts a twisted conformation with puckering parameters q
2 = 0.088 (3) Å and Φ2 = 61.5 (14)°. The cyclopentane ring adopts a twisted conformation with puckering parameters q
2 = 0.099 (2) Å and Φ2 = 242.8 (14)°. A weak intramolecular O—H⋯O interaction occurs. In the crystal, pairs of C—H⋯O interactions generate dimers with graph-set motif R
2
2(24) and they are interconnected by pairs of O—H⋯O hydrogen bonds, which link the molecules into inversion dimers with graph-set motif R
2
2(10).
The asymmetric unit of the title compound, C 21 H 15 Cl 2 N 5 O 4 , contains two independent molecules (A and B) having similar conformations. The amine (NH 2 ) group forms an intramolecular hydrogen bond with the benzoyl group, giving an S(6) ring motif in both molecules. The central six-membered rings adopt sofa conformations and the imidazole rings are planar (r.m.s deviations = 0.0150 and 0.0166 Å ). The pyridine and imidazole rings are inclined to one another by 3.54 (1) and 3.03 (1) in molecules A and B, respectively. In the crystal, molecules are linked by N-HÁ Á ÁO hydrogen bonds, forming chains along the a axis which enclose R 2 2 (16) ring motifs. The rings are linked by weak N-HÁ Á ÁO and C-HÁ Á ÁO hydrogen bonds and C-HÁ Á Á interactions forming sheets lying parallel to (001). A region of disordered electron density, most probably disordered solvent molecules, occupying voids of ca 753 Å 3 for an electron count of 260, was treated using the SQUEEZE routine in PLATON [Spek (2009) D65, 148-155]. Their formula mass and unit-cell characteristics were not taken into account during refinement. . Acta Cryst.
The title compound comprises a 2-iminopyridine ring fused with a cyclooctane ring, which adopts a twist boat–chair conformation. Intermolecular C—H⋯N interactions form (14) ring motifs and molecules are further connected by weak C—H⋯π interactions.
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