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The etiology of vitiligo is still unclear. The aim is to investigate a neural and hormonal etio-pathology of vitiligo. Sixty acrofacial vitiligo patients were divided into two subgroups as active vitiligo patients group (AVPs; n = 35) and stable vitiligo patients group (SVP; n = 25). Forty healthy subjects without any systemic or dermatological disease were used as controls. Blood samples were collected, and the samples were used for measurement of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), cortisol, estrogen, testosterone, melatonin, and prolactin levels by ELISA, while norepinephrine (NE), epinephrine (Epi), dopamine (DA), homo-vanillic acid (HVA), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) by high-pressure liquid chromatography. The current results showed a significant increase in plasma levels of Epi, NE, DA, HVA, serotonin, 5-HIAA, melatonin, and in serum level of TSH and prolactin either in SVP or AVP groups than the control group and in AVP than SVP group. The serum levels of fT3 and fT4 were significantly decreased either in SVP or AVP groups than the control group. A significant increase in estradiol levels was observed in females within AVP than females in either SVP or control groups. There was a significant increase in serum level of cortisol in AVP than either SVP or control group. There was a significant decrease in serum level of ACTH in either AVP or SVP than control and in AVP than SVP group. In conclusion, there are some neural and endocrine markers that play a pivotal role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of theses markers lead to melanocyte destruction and/or depigmentation.

Background and purpose: Children with hemophilia often bleed inside the joints and muscles, which may impair postural adjustments. These postural adjustments are necessary to control gait and postural balance during daily activities. The inability to quickly recover postural balance could elevate the risk of bleeding.So, the purpose of this study was to compare between the effects of bicycle ergometer and treadmill on balance and gait parameters in children with hemophilia.Materials and methods: Thirty hemophilic boys with the ages ranging from 10 to 14 years had participated in this study. They were assigned randomly into two equal study groups. Group A received a designed physical therapy program and aerobic exercise training by bicycle ergometer. While group B received the same physical therapy program in addition to aerobic exercise training by the treadmill. Both groups received treatment sessions three times per week for three successive months. Stability indices and kinematic gait parameters were evaluated before and after three successive months of treatment.Results: There were non significant differences between the pre-treatment mean values of all measuring variables for the two groups. Significant improvement was observed in the two groups when comparing their pre and post treatment mean values. Also, significant differences were recorded when comparing the post treatment results of the two groups in favor of the study group B.Conclusion: Aerobic exercise, in the form of treadmill training for children with hemophilia, is an excellent supplement to regularly scheduled physical therapy intervention. It improves the degree of stability and gait parameters for those patients. Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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Th is study was conducted to determine the interaction between chickpea genotypes with the environment (GxE) on the yield stability and adaptability of desi type chickpea genotypes (Cicer arietinum L.). Seventeen chickpea genotypes were evaluated for two cropping years (2012/2013 -2013/2014) at four locations i.e., eight environments (locations x years combination). Chickpea grain yield was significantly (p<0.01) affected by genotypes, the environments and GxE interaction, indicating that the varieties and the test environments were diverse. GxE was further partitioned by principal component axes. The first two principal components cumulatively explained 53.1% of the total variation, of which 32.7% and 20.4% were contributed by IPCA1 and IPCA2, respectively. This implies that the interaction of 17 chickpea genotypes with eight environments was predicted by the first two principal components. AMMI1 biplot analysis showed five adaptive categories of genotypes based on similarities in their performance across environments. The AMMI2 biplot generated using genotypes and environmental scores for the first two IPCAs revealed positioning of the five genotype groups (GC) into four sectors of the biplot. Among them, two genotypes in GC 5 (G5 and G11) exhibited high yields across environments, low IPCA1 scores, low AMMI stability value (ASV) and yield stability index (YSI). G5 was released as a new variety, 'Dimtu' and registered in the Official Varieties Catalogue of Ethiopia, 2016.

Continuum equations governing thermal non-equilibrium modeling of steady natural convection inside wavy enclosures with the effect of thermal radiation are developed. These equations account for such effects as the inter-phase heat transfer coefficient effect, the thermal radiation effect, the modified conductivity ratio effect and the Rayleigh number effect. Finite difference method is employed to solve these equations and comparisons between previous published works are presented. Numerical results for the flow and heat transfer for the fluid and solid phases are obtained for various combinations of the physical parameters. Graphical and tabular results illustrating interesting features of the physics of the problem are presented and discussed.