In DNA computing, the design of DNA code is the most important step. The definition of DNA code, the constraints of DNA encoding and the corresponding formula are firstly described in this article, and then the design of DNA encoding based on immune clone algorithm is introduced. Simulation experiments show that DNA molecular chains that satisfy specific constraints and the corresponding thermodynamic characteristics can be produced based on immune clone selection algorithm. Using immune clone selection algorithm can improves the efficiency of encoding by, and using a series of constraints can produce very stable DNA sequences. It laid a good foundation for DNA computing.
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