Video streaming is crucial for AI applications that gather videos from sources to servers for inference by deep neural nets (DNNs). Unlike traditional video streaming that optimizes visual quality, this new type of video streaming permits aggressive compression/pruning of pixels not relevant to achieving high DNN inference accuracy. However, much of this potential is left unrealized, because current video streaming protocols are driven by the video source (camera) where the compute is rather limited. We advocate that the video streaming protocol should be driven by real-time feedback from the server-side DNN. Our insight is twofold: (1) server-side DNN has more context about the pixels that maximize its inference accuracy; and (2) the DNN's output contains rich information useful to guide video streaming. We present DDS (DNN-Driven Streaming), a concrete design of this approach. DDS continuously sends a low-quality video stream to the server; the server runs the DNN to determine where to re-send with higher quality to increase the inference accuracy. We find that compared to several recent baselines on multiple video genres and vision tasks, DDS maintains higher accuracy while reducing bandwidth usage by upto 59% or improves accuracy by upto 9% with no additional bandwidth usage.

The practical use of luminescent mononuclear gold(I) complexes as optoelectronic materials has been limited by their inferior stability. Herein we demonstrate a strategy to improve the stability of gold(I) complexes which display thermally activated delayed fluorescence (TADF). A highly rigid and groove‐like σ‐donating aryl ligand has been used to form dual Au⋅⋅⋅H−C hydrogen bonds. The secondary metal‐ligand interactions have been authenticated by single‐crystal structure, NMR spectroscopy and theoretical simulations. The TADF AuI complex exhibits appealing emission properties (photoluminescence quantum yield=76 %; delayed fluorescence lifetime=1.2 μs) and much improved thermal and photo‐stability. Vacuum‐deposited organic light‐emitting diodes (OLEDs) show promising electroluminescence with a maximum external quantum efficiency (EQE) over 23 % and negligible efficiency roll‐off even at 10 000 cd m−2. An estimated LT50 longer than 77 000 h with initial luminance of 100 cd m−2 reveals good operational stability. This work suggests a way for design of stable luminescent gold(I) complexes.

Heparan sulfate (HS) has important emerging roles in oncogenesis, which represents potential therapeutic strategies for human cancers. However, due to the complexity of the HS signaling network, HS-targeted synthetic cancer therapeutics has never been successfully devised. To conquer the challenge, we developed HS-instructed self-assembling peptides by decorating the "Cardin−Weintraub" sequence with aromatic amino acids. The HS-binding interactions induce localized accumulation of synthetic peptides triggering molecular self-assembly in the vicinity of highly expressed Heparan sulfate proteoglycans (HSPGs) on the cancer cell membrane. The nanostructures hinder the binding of HSPG with metastasis promoting protein−heparin-binding EGF-like growth factor (HBEGF) inhibiting the activation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). Our study proved that HS-instructed self-assembly is a promising synthetic therapeutic strategy for targeted cancer migration inhibition.

Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis.