Recently, extending single-atom catalysts
from mono- to binary
sites has been proved to be a promising way to realize more efficient
chemical catalytic processes. In this work, atomically dispersed Fe,
Pt dinuclear catalysts ((Fe, Pt)SA-N-C) with an ca. 2.38 Å distance for Fe1 (Fe-N3) and Pt1 (Pt-N4) could be precisely controlled
via a novel secondary-doping strategy. In response to tumor microenvironments,
the Fe-N3/Pt-N4 moieties exhibited synergistic
catalytic performance for tumor catalytic therapy. Due to its beneficial
microstructure and abundant active sites, the Fe-N3 moiety
effectively initiated the intratumoral Fenton-like reaction to release
a large amount of toxic hydroxyl radicals (•OH),
which further induced tumor cell apoptosis. Meanwhile, the bonded
Pt-N4 moiety could also enhance the Fenton-like activity
of the Fe-N3 moiety up to 128.8% by modulating the 3d electronic orbitals of isolated Fe-N3 sites.
In addition, the existence of amorphous carbon revealed high photothermal
conversion efficiency when exposed to an 808 nm laser, which synergistically
achieved an effective oncotherapy outcome. Therefore, the as-obtained
(Fe, Pt)SA-N-C-FA-PEG has promising potential in the bio-nanomedicine
field for inhibiting tumor cell growth in vitro and in vivo.
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