Immunosuppressive drugs and biological agents may represent a potential risk of
lymphoma development in patients with rheumatoid arthritis. But most cases are
diffuse, large B-cell lymphomas. Primary cutaneous CD4+ small/medium-sized
pleomorphic T-cell lymphoma, a provisional entity in the 2005 WHO-EORTC
classification of cutaneous lymphomas, is only described in a limited number of
reports. To our knowledge, our case is a rare instance of primary cutaneous CD4+
small/medium-sized pleomorphic T-cell lymphoma, after associated treatment with
methotrexate and etanercept, in a patient with moderate rheumatoid arthritis who
had undergone an orchidectomy incorrectly.
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