The field of living materials seeks to harness living cells as microfactories that can construct a material itself or enhance the performance of material in some manner. While recent advances in 3D printing allow microbe manipulation to create bespoke living materials, the effective coupling of these living components in reinforced bioink designs remains a major challenge due to the difficulty in building a robust and cell‐friendly microenvironment. Here, a type of dual‐network bioink is reported for the 3D printing of living materials with enhanced biocatalysis capabilities, where bioinks are readily printable and provide a biocompatible environment along with desirable mechanical performance. It is demonstrated that integrating microbes into these bioinks enables the direct printing of catalytically living materials with high cell viability and maintains metabolic activity, which those living materials can be preserved and reused. Further, a bacteria‐algae coculture system is fabricated for the bioremediation of chemicals, giving rise to its potential field applications.
Temporal fascia, tragus perichondrium, and tragus cartilage-perichondrium composite grafts are all suitable for myringoplasty after a minor tympanic membrane perforation. However, cartilage-perichondrium composite graft material for myringoplasty has superior long-term benefits in regard to both hearing improvements and tympanic membrane morphology, which are especially evident in cases with large perforations.
The preparation of dual-release pharmaceutical microfibers provides an ideal material for new biomedical applications. We describe a microfluidic spinning method for engineering heterotypic bead-on-string fibers with the ability to carry...
A numerical method is proposed for solving a sort of constrained continuous minimax problem, in which both the objective function and the constraint functions are continuously differentiable about superior decision variables and are continuous about lower decision variables .Besides,the constraint functions include only superior or lower decision variables.The problem is transformed into unconstrained differentiable problem with the idea of the discrete maximum entropy function and the continuous maximum entropy function and the penalty function method.The basic algorithm is established.The convergence is proofed.Numerical examples are given and show the efficiency and the reliability of the algorithm.
Carbon/Carbon composite is considered to be one of the best biomaterials substitute to human hard tissues due to its excellent biocompatibility and the much closed elastic modulus to human skeleton. It has been widely used and studied to the fields of artificial bones materials, but the osteoinductivity need to be improved. In recent years, the commonly used surface modification to improve their bone induction, such as hydroxyapatite, chitosan and so on, which prompted the adsorption of osseous protein, adhesion and growth of cells. It is believed the surface modification and coating of the carbon/carbon composite should promote its application in artificial bones. This article reviews the modified coat of medical carbon / carbon composites in recent years, and proposed some recommendations for the development of medical carbon / carbon composite in the future.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.