In
this study, a novel protocol consisting of peroxidatic reaction
and epoxidation process was developed. Besides, a specific continuous
extraction apparatus was also employed in the continuous flow synthesis
process. Without additional purification, m-chloroperbenzoic
acid (m-CPBA) generated in situ could react with cyclohexene, leading
to high quality cyclohexene oxide. In the first stage, m-CPBA was
obtained within a few seconds at room temperature by reacting m-chlorobenzoyl chloride with hydrogen peroxide, while cyclohexene
oxide was prepared at 30 °C for 10 min in the following stage.
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