It
is important to study the bactericidal mechanism with nanostructures
for the design and preparation of high-efficiency sterilization materials.
In this paper, the interfacial energy gradient between cells and nanopillars
is proposed to be the driving force to promote cells to migrate into
nanostructures and get killed. The expressions of interfacial energy
and its gradient were first established, then the deformation of cells
pressured by nanostructures was calculated. The results show that
the interfacial energy gradient or the pressure on cells is influenced
by nanopillar parameters substantially. The smaller the nanopillar
diameter and the larger the pitch, the greater the pressure on cells.
Only high enough nanocolumns can ensure sufficient cell creep deformation
and become punctured. Furthermore, a cell volume and its adhesion
morphology also influence the interaction between cells and nanostructures.
The smaller the cell volume, the greater the pressure on it. And the
larger the contact angle of adhered cells, the greater the pressure
on the cells by nanopillars. Besides, the wettability of substrate
material also influences the interaction between cells and nanopillars.
It can be concluded that the model is reasonable and reliable since
its calculation results are in good accordance with the experimental
measurements.
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