A novel and efficient copper-catalyzed transannular ring-closing reaction of eight-membered rings has been developed that provides a straightforward way to synthesize bicyclo[3.3.0]octane derivatives in good yields. Mechanistic studies revealed that the reaction pathway might involve chlorination followed by the Kornblum reaction. Readily accessible starting materials and good functional group tolerance make this procedure attractive.
A novel base‐promoted and highly efficient strategy for preparation of trifluoromethyl‐containing tetrasubstituted olefin derivatives has been developed. The trifluoroacetyl amination of alkynes is realized by C−N cleavage of trifluoroacetamides without any transition‐metal catalysts. Readily accessible substrates, good functional group tolerance and atom economy make this approach attractive for the synthesis of trifluoromethyl‐containing tetrasubstituted olefins.
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