Our study provides direct evidence showing that DNA hypomethylation is essential for apoptotic DNA to induce SLE-like autoimmune disease in non-susceptible mice, which may help in elucidating the pathogenesis of SLE.

A three-dimensional paper-based microfluidic device (3D-PMED) has been developed for dynamic sweat metabolite monitoring with continuous sweat flow avoiding accumulation.

The aim of the present study was to investigate the antioxidant and hepatoprotective effects of water-soluble polysaccharides (RVLWP) and alkali-soluble polysaccharides (RVLAP) from Russula vinosa on carbon tetrachloride (CCl4)-induced acute liver damage in mice. For the in vitro antioxidant activities, RVLWP and RVLAP exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (IC50 = 1.55 ± 0.04 and 3.37 ± 0.21 mg/mL, respectively), hydrogen peroxide scavenging activity (IC50 = 6.07 ± 0.24 and 9.23 ± 0.54 mg/mL, respectively), lipid peroxidation inhibitory effect (IC50 = 0.52 ± 0.095 and 0.86 ± 0.043 mg/mL, respectively), and moderate reducing power and Fe(2+) chelating activity (IC50 = 1.86 ± 0.0036 and 0.22 ± 0.0057 mg/mL, respectively). Ascorbic acid was employed as the standard antioxidant in the present study. For the in vivo hepatoprotective activity, administration of RVLWP and RVLAP (200 mg/kg) significantly prevented the elevation in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in acute liver damage induced by CCl4 and suppressed hepatic malondialdehyde (MDA) formation. Mice treated with RVLWP and RVLAP demonstrated a better profile of antioxidants with augmented activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the liver. The results suggest that RVLWP and RVLAP protect the liver from CCl4-induced hepatic damage via antioxidant mechanisms.

No abstract

Here, a smartwatch for sweat monitoring was presented for perspiration analysis. The smartwatch played the part of analyzing, computing, and displaying the real‐time data with the feature of comfortable wearing and lightweight ergonomic design. Moreover, the paper‐based microfluidic patch with a three‐dimensional structure was proposed to realize the sweat collection and solve the issue of sweat accumulation. To further realizing the sweat monitoring, the potassium and sodium ion‐selective electrodes were developed by the screen‐printing technique. The experiment of on‐body monitoring the K+ and Na+ in sweat had been carried out to further demonstrate the feasibility of the smartwatch.

No abstract

Selection of the most appropriate contractor for the installation of solar panels is essential to maximizing the benefit of this renewable, sustainable energy source. Solar energy is one of the 100% renewable energy sources, but implementation may not be very simple and cost-effective. A key phase in the implementation of renewable energy is the evaluation of contractors for the installation of solar panels, which is addressed as a multi-criteria decision-making (MCDM) problem. A new hybrid method is proposed that combines the stepwise weight analysis ratio assessment (SWARA) and full consistent method (FUCOM) weights that are represented as grey numbers used with traditional grey relational analysis (GRA) and evaluation based on distance from average solution (EDAS) methods. The ranking of contractors by both methods is the same, which confirmed the results presented in this research. The use of the grey SWARA-FUCOM weighting method combined with the GRA and EDAS methods increased the decision-makers’ (DMs) confidence in awarding the installation of the solar panel energy system to the top-ranked contractor.

Vertically aligned PANI nanorod arrays uniformly distributed on GO nanosheets for a highly sensitive ammonia sensor.