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The mechanical properties and seepage characteristics of gas-bearing coal evolve with changes in the loading pattern, which could reveal the evolution of permeability in a protected coal seam and allow gas extraction engineering work to be designed by using the effect of mining multiple protective seams. Tests on gas seepage in raw coal under three paths (stepped-cyclic, stepped-increasing-cyclic, and crossed-cyclic loading and unloading) were carried out with a seepage tester under triaxial stress conditions. The permeability was subjected to the dual influence of stress and damage accumulation. After being subjected to stress unloading and loading, the permeability of coal samples gradually decreased and the permeability did not increase before the stress exceeded the yield stage of the coal samples. The mining-enhanced permeability of the coal samples in the loading stage showed a three-phase increase with the growth of stress and the number of cycles and exhibited an N-shaped increase under the stepped-cyclic loading while it linearly increased under the other two paths in the unloading stage. With the increase of peak stress and the accumulation of damage in coal samples, the sensitivity of the permeability of coal samples to stress gradually declined. The relationship between the damage variable and the number of cycles conformed to the Boltzmann function.