A library consisting of a series of O,O′-diaryzoyl-L-(-)-tartaric acids (2) was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol (1). Excellent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However, a family of three resolving reagents failed to improve the resolution efficiency of rac-1.
resolution of albuterol, O,O′-diaryzoyltartaric acids, parallel resolution, family resolution Citation:Zhong Q L, Peng X H, Wu T F, et al. A parallel approach to direct resolution of albuterol.
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