Clinically significant portal hypertension (CSPH) is associated with an incremental risk of esophageal varices and overt clinical decompensations. However, hepatic venous pressure gradient (HVPG) measurement, the gold standard for defining CSPH (HVPG≥10 mm Hg) is invasive and therefore not suitable for routine clinical practice. This study aims to develop and validate a radiomics-based model as a noninvasive method for accurate detection of CSPH in cirrhosis.The prospective multicenter diagnostic trial (CHESS1701, ClinicalTrials.gov identifier: NCT03138915) involved 385 patients with cirrhosis from five liver centers in China between August 2016 and September 2017. Patients who had both HVPG measurement and contrast-enhanced CT within 14 days prior to the catheterization were collected. The noninvasive radiomics model, termed rHVPG for CSPH was developed based on CT images in a training cohort consisted of 222 consecutive patients and the diagnostic performance was prospectively assessed in 163 consecutive patients in four external validation cohorts.rHVPG showed a good performance in detection of CSPH with a C-index of 0·849 (95%CI: 0·786–0·911). Application of rHVPG in four external prospective validation cohorts still gave excellent performance with the C-index of 0·889 (95%CI: 0·752–1·000, 0·800 (95%CI: 0·614–0·986), 0·917 (95%CI: 0·772–1·000), and 0·827 (95%CI: 0·618–1·000), respectively. Intraclass correlation coefficients for inter- and intra-observer agreement were 0·92–0·99 and 0·97–0·99, respectively.A radiomics signature was developed and prospectively validated as an accurate method for noninvasive detection of CSPH in cirrhosis. The tool of rHVPG assessment can facilitate the identification of CSPH rapidly when invasive transjugular procedure is not available.

Objectives/research questions: The present study focused on the performance of Chinese learners of English to investigate the activation of morpho-semantic information in the early processing of second language (L2) morphologically complex words when participants' first language (L1) and L2 are typologically different. Methodology: We used forward masked priming paradigm to compare the priming effect in three prime conditions, semantically transparent, semantically opaque and semantically related. In Experiment 1, the stimulus onset asynchrony (SOA) was 40 milliseconds (ms), while, In Experiment 2, the SOA was extended to 80 ms. Data and analysis: Reaction time and comprehension accuracy data were analysed using the linear mixed-effects model. Findings/conclusions: In Experiment 1, we only found a priming effect in the semantically transparent condition. In Experiment 2, we found a reliable priming effect in the semantically opaque condition, but not in the semantically related condition. These results suggest even Chinese learners of English whose native language is typologically different from English can

To improve the tribological properties of pure MoS2 coating, the MoS2–Zr composite lubricating coatings were prepared on the WC/TiC/Co carbide surface utilizing radio frequency magnetron sputtering method combining with multiple arc ion plating technology. The effects of different Zr target currents on the surface morphologies, roughness, Zr content, adhesive force, thickness, microhardness and tribological behaviors of the composite coatings were systematically investigated. Results showed that the properties of MoS2 coating can be remarkably enhanced through co-deposition of a certain amount of Zr. As the Zr target current increased, the Zr content, surface roughness, thickness, and micro-hardness gradually increased, while the adhesive force of coatings increased first and then decreased. The friction behaviors and wear modes of the composite coatings both varied obviously with the increase of Zr current. The mechanism was mainly attributed to the different components and mechanical properties of the coatings caused by various Zr current.

Objectives A liver stiffness × spleen size/platelet count score (LSPS) model which can rule out high-risk varices and identify high likelihood of clinically significant portal hypertension in patients with compensated cirrhosis has been endorsed by American Association for the Study of Liver Diseases in the 2016 practice guidance on portal hypertension bleeding. This study aims to evaluate the accuracy of LSPS model assessed by ultrasound in well characterized patients with compensated advanced chronic liver disease. Methods Eligible patients with compensated advanced chronic liver disease were retrospectively enrolled between January 2017 and March 2018, who had undergone routine clinical and laboratory tests, liver stiffness measurement, ultrasound examination, and computed tomography scanning. Spleen sizes were evaluated by ultrasound and computed tomography reconstructed model, respectively. The correlation and agreement of spleen size and LSPS derived from ultrasound and computed tomography imaging modality were compared. Results A total of 158 patients were included and analyzed. Spleen size showed a moderate correlation (R = 0.649, P < 0.001) according to ultrasound and computed tomography imaging. Also, the correlation between the two LSPS models based on ultrasound and computed tomography was excellent (R = 0.985, P < 0.001). The Bland–Altman plots demonstrated a superior agreement of LSPS model values evaluated by ultrasound and computed tomography, respectively. Conclusion This study demonstrated the accuracy of LSPS model based on ultrasound in a well characterized cohort of fully compensated patients with advanced chronic liver disease.

Abstract. In recent years, the development of the computer and GIS technology brings many new methods for the military highway transportation. In this paper, several key technologies to establish the road topology structure based on MapX are discussed, and an algorithm for finding the shortest path in the damaged road network based on MapX is presented. Finally, some example is used to illustrate the procedure of finding the best path on digital map, and the results show that this algorithm can obviously improve the efficiency of military command.

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The water heater of an air source heat pump has the disadvantages of high exhaust temperature and weak heating performance in a cold area. The quasi two-stage compression cycle technology can effectively improve its operation characteristics in the cold area. In this paper, a rotor compressor with a medium pressure air supply is used to develop the water heater with R410A as the circulating working fluid. The system's heating performance under low temperature environments is experimentally studied. The results show that the exhaust temperature of the water heater system with the medium pressure air supply is lower than those without the air-supply system.